COOPERATIVE FERMENT STRENGTH REGULATION
Regulation by means of cooperativity is one of the types of ferment strength regulation. Cooperativity is characteristic of multi-subunit proteins, including ferments. If cooperativity takes place, then kinetic properties of a ferment cannot be described by the Michaelis-Menten equation. With cooperativity, a small increasing of concentration of the substrate causes considerable increasing of the reaction rate. To explain this effect different models were suggested. The most famous of them are Monod, Wyman and Changeux (symmetrical) models, and also, Koshland, Nemethy and Filmer (sequential) models.
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Supplementary information
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