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RETRO INHIBITION

Retro inhibition, or, feedback inhibition, is one of the ways of ferment strength regulation. The process is associated with activity of an inhibitor in a metabolic chain, in which the substrate suffers several successive transformations, where each reaction is catalyzed by its own ferment. Inhibition takes place, if the final product blocks up one of the previous stages in the reaction chain. For this the final product must either structurally resemble the substrate of the reaction having been blocked up (that is, to act as a competitive inhibitor), or, to be bonded with some other part of the ferment and regulate its activity in such a way (that is, appears as a noncompetitive inhibitor).